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Drug Information Drugs That Deplete Nutrients How to...  
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Drugs that Deplete Nutrients

Helping Patients Replenish Nutrients Depleted By Common Prescription and OTC Medications

The use of prescription and over-the-counter drugs is extremely prevalent in North America and in most of the Western developed world. It is reported that 46 percent of Americans take at least one prescription drug daily. In 2005, the Minnesota Board on Aging demonstrated that for individuals over the age of 65, 21 percent took five or more prescription drugs every day; 25 percent took three to four prescription drugs per day; 36 percent took one to two prescription drugs per day, while only 18 percent did not take any prescription drugs on a daily basis. Although many individuals do not have formal training in pharmacology, it is at the very least, important for people to be aware of the nutrient depletion that can result from the use of certain medications. What is evident from the information that follows is that taking a high quality multiple vitamin enriched with antioxidants, B complex and 350-500 mg of calcium is an important consideration to counter drug-induced nutrient depletion, as well as being a cornerstone of wellness care for most adults. The following is a summary of nutrients depleted by commonly used drugs:

Laxatives are associated with depletion of the following nutrients:

Vitamin A

Vitamin D

Vitamin E

Calcium

Antibiotics are associated with depletion of the following nutrients:

Vitamin B1

Vitamin B2

Biotin

Pantothenic Acid

Vitamin C

Vitamin E

Vitamin K

Potassium

Magnesium

Zinc

Cholesterol-lowering drugs, such as Cholestyramine, Colestipol, Questran, Colestid and

Atromid-S, are associated with depletion of the following nutrients:

Vitamin A

Vitamin B12

Beta-carotene

Folic Acid

Vitamin D

Vitamin E

Vitamin K

Iron

Colchicine, used to treat gout, is associated with depletion of the following nutrients:

Vitamin A

Vitamin D

Vitamin B12

Folic Acid

Iron

Prednisone and related steroid drugs are associated with depletion of the following nutrients:

Folic Acid

Vitamin D

Zinc

Magnesium

Vitamin C

Calcium

Nonsteroidal, anti-inflammatory drugs (NSAIDs), including aspirin, are associated with

depletion of the following nutrients:

Folic Acid

Vitamin C

Vitamin K

Iron

Antacid drugs are associated with depletion of the following nutrients:

Vitamin A

Vitamin B1

Folic Acid

Vitamin B12

Chromium

Iron

Oral contraceptive drugs are associated with depletion of the following nutrients:

Beta-carotene

Vitamin B1

Vitamin B6

Folic Acid

Vitamin B12

Biotin

Pantothenic Acid

Vitamin C

Magnesium

Zinc

Sedatives and barbiturates are associated with depletion of the following nutrients:

Vitamin B2

Vitamin C

Vitamin D

Folic Acid

Vitamin B12

Pantothenic Acid

Estrogen-replacement therapy is associated with depletion of the following nutrients:

Vitamin B1

Vitamin B2

Folic Acid

Vitamin B12

Biotin

Pantothenic Acid

Vitamin C

Magnesium

Many anti-depressants are associated with depletion of the following nutrients:

Vitamin B2

Vitamin B6

Calcium

Magnesium

Coenzyme Q10

Amphetamine and amphetamine-containing drugs are associated with the depletion of vitamin B1.

Levodopa, used in the treatment of Parkinson's disease, is associated with depletion of

vitamin B6.

Many anti-convulsant drugs are associated with depletion of the following nutrients:

Folic Acid

Biotin

Vitamin D

Vitamin E

Zinc

Digoxin (digitalis) is associated with depletion of vitamin B1. Indomethacin is also associated

with depletion of vitamin B1.

Diuretic drugs are associated with depletion of the following nutrients:

Vitamin B1

Calcium

Potassium (thiazide drugs especially)

Magnesium

Zinc

Angiotensin-converting enzyme inhibitor drugs, used for high blood pressure, are associated

with depletion of zinc. Beta-blockers, also used in the treatment of high blood pressure, are

associated with depletion of coenzyme Q10. Statin drugs (e.g., Lipitor), used in the treatment of

high cholesterol, are associated with depletion of coenzyme Q10.

Resources

1. Bowman L. "51% of U.S. Adults Take 2 Pills or More a Day, Survey Reports." (Scripps

Howard News Service). San Diego Union-Tribune, Jan. 17, 2001:A8.

2. Krogh CME, Ed. Compendium of Pharmaceuticals and Specialties, 25th ed. Ottawa:

Canadian Pharmaceutical Assoc., 1990.

3. Pressman AH. Clinical Assessment of Nutritional Status: A Working Manual.

Management Enterprises, 1982.

4. Alpers DH, Clause RE, Stenson WF. Manual of Nutritional Therapeutics, 2nd ed. Little,

Brown and Company, 1988.

5. Kreutler PA, Csajka-Nairns DM. Nutrition in Perspective, 2nd ed. Englewood Cliffs, NJ:

Prentice-Hall, Inc., 1987.

6. Long PJ, Shannon B. Focus on Nutrition Englewood Cliffs, NJ: Prentice-Hall, Inc., 1983.

7. Howard EJ. Health Risks. The Body Press, 1986.

8. Simone CB. Cancer and Nutrition, Revised and Expanded Edition. Avery Publishing

Group, Inc, 1992.

9. American Journal of Clinical Nutrition. January 1991;53(Suppl 1).

10. Rybacki JJ, Long JW. The Essential Guide to Prescription Drugs. Harper Resource,

2001.

11. Kantner MM, et al. Medicine and Science in Sports and Exercise. April 1990;22(2).

12. Shannon S. Diet for the Atomic Age. Avery Publishing Group, Inc., 1987.

13. Reavley N. New Encyclopedia of Vitamins, Minerals, Supplements and Herbs. New

York: M. Evans & Co. Inc., 1998.

14. Drugs That Deplete – Nutrients That Heal: A review of Drug-Induced Nutrient Depletion

Handbook, 1999-2000. Life Extension Magazine, July 2000.

15. Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase inhibitors and

the associated depletion of coenzyme Q10: a review of animal and human publications.

Biofactors, 2003;18(1-4):101-11.

   

 

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